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Gut microbiome signatures modulate cardiovascular disease risk

Cardiovascular disease related death remains the biggest killer worldwide, and despite knowledge of the In a new study from China, researchers have identified a relationship between the gut microbiome, metabolism and cardiovascular disease risk.
Using a discovery cohort of 10,207 individuals aged between 40-93 years, they identified five metabolic clusters, ranging from metabolically healthy to hyperglycaemic.  Those individuals within the hyperglycaemic cluster had an increased risk by 75% for developing cardiovascular disease within an 11.1-year period. Additionally, the authors developed a gut microbial age metric using 55 age-specific microbial species, identifying that cardiovascular disease risk increases with microbial age.
The results from this study support modulating the microbiome of metabolically unhealthy older people to reduce cardiovascular disease risk.