Safina Gadeock
Posts by Safina Gadeock for News
Anti-TNF therapy for IBD patients is associated with increased risk to Immune Mediated Inflammatory Diseases
Anti-TNFs are primary therapies for several immune-mediated inflammatory diseases (IMIDs). However, case studies have revealed the paradoxical occurrence of IMIDs in patients treated with anti-TNF. The authors in this study conducted 2 nationwide cohort studies comprising all patients with IBD in Denmark (2005–2018) and France (2008–2018). They showed that anti-TNF was associated with an increased risk of rheumatoid arthritis, psoriasis, and hidradenitis suppurativa in both the Danish and the French cohort. Anti-TNF was also associated with an increased risk of the outcomes when compared with azathioprine suggesting that anti-TNF therapy was associated with an increased risk of rheumatoid arthritis, psoriasis, and hidradenitis suppurativa.
Vedolizumab supports intestinal stem cell recovery.
A recent study from the University of California, San Francisco showed that Vedolizumab (VDZ), an anti-integrin antibody, effective in the treatment for Colitis, plays an important role in limiting specific inflammatory immune, fibroblasts and endothelial cells to facilitate intestinal epithelial stem cell recovery. By using a combination of latest sequencing technologies, they provide a tool for comprehensive analysis of the inter cellular networks of the colon in health, disease, and during treatment. Implementing these new single-cell and spatial technologies simultaneously in individual patients will lead to more precise treatment algorithms, and therefore a way for precision medicine.
Click on the link below to see the study
https://www.nature.com/articles/s41467-024-45665-6?fromPaywallRec=false#Sec2